Pharm(AIMS nov2007)

1.OC pills are contraindicated in patients receiving:
a. Rifampicin
b. Ethambutol
c. Streptomycin
d. Pyrazinamide

Ans--A

2.True about fibrates is all except:
a. (MOA)….PPARα….lipoprotein lipase…decreased LDL…
b. Absorped better on empty stomach and decreased on food intake
c. Side effects include rash, myalgia, impotence and many others
d. They are the drug of choice in type III hyperlipidemia and hypertriglyceridemia

Ans—B

3.True about Benzodiazepines as compared to other hypnotics is:
a. They alter sleep pattern more than other hypnotics
b. More sedative than other hypnotics
c. Overdose is better tolerated compared to other hypnotics

d. .. Ans—C

4.Thiazides cause all except:
a. Hyperglycemia
b. Increased calcium excretion
c. Increased uric acid excretion
d. Useful in congestive heart failure

Ans—B

5.Regarding furosemide, true is:
a. Given by parenteral route only
b. Used in pulmonary oedema
c. Acts at the PCT
d. Causes hypercalcemia

Ans—B

6.Uterine relaxant with the least side effect:
a. Ritodrine
b. MgSO4
c. Nifedipine
d. Progesterone

Ans—B

7.Bisphosphonates are not used in:
a. Hypercalcemia
b. Osteoporosis
c. Cancer
d. Vitamin D intoxication

Ans—D

8.True about protease inhibitors are all except:
a. Acts as a substrate for P-glycoprotein(P-gp) and action is mediated by MDR-1 gene
b. Hepatic oxidative metabolism
c. All protease inhibitors interfere with metabolism by drug interactions
d. Saquinavir causes maximum induction of CYP3A4

Ans-D

9.Therapeutic monitoring is done for all of the following except:
a. Tacrolimus
b. Metformin
c. Cyclosporine
d. Phenytoin

Ans—B

10.Antiemetic with most "affinity" for "5Ht3" is:
a. Ondansetron
b. Granisetron
c. Dolasetron
d. Pavalosetron

Ans—D

11.Regarding Phenytoin,false is:
a. Induces microsomal enzymes
b. At very low doses, zero order kinetics occurs
c. Higher the dose,higher is the half life
d. Highly protein bound

Ans—B

12.Hyperglycemia is caused by:
a. Beta blockers
b. Glucocorticoids
c. NSAID
d. ..

Ans—B

13.Which of the following is not used as a sedative,but causes sedation as a side effect:
a. Digitalis,anti-arrhythmics
b. Antihistaminics,antidepressants
c. Macrolides,…
d. ..

Ans—B

14.All but one acts via GABA Aexcept:
a. Thiopentone
b. Midazolam
c. Zolpidem /zopiclone
d. Promethazine

Ans--D

15.A patient is posted for elective surgery. Which of the following drugs should be stopped on the day of surgery:
a. Atenolol
b. Amlodepine
c. Statins
d. Metformin

Ans—D

16Hypercalcemia is caused by all except:
a. Loop diuretics
b. Lithium
c. Vitamin D intoxication
d. ..

Ans—A

17.All of the following can be used for thromboprophylaxis except:
a. Heparin
b. Aspirin
c. Warfarin
d. Antithrombin-III Ans—D

18.Used for the treatment of migraine, the triptans act through:
a. 5HT-1A
b. 5HT-1B
c. 5HT-1F
d. 5HT-3

Ans—B

19.Good clinical practices required in all except
a. preclinical phase
b. phase 1
c. phase 2
d. phase 4

Ans--A