MEN Syndrome

MEN Syndrome

Men is of two types that is Type1 and Type 2
Type2 is again of three types i.e
1.MEN 2a Syndrome (Sipple's Syndrome)
2.MEN 2b Syndrome
3.FMTC.


Multiple endocrine neoplasia type 1 (MEN 1). This autosomal dominant endocrinopathy is genetically and clinically distinct from MEN 2; however, the similar nomenclature for MEN 1 and MEN 2 may cause confusion. MEN 1 is caused by mutations in the MEN 1 gene. MEN 1 is characterized by a triad of pituitary adenomas, pancreatic islet cell tumors, and parathyroid disease consisting of hyperplasia or adenoma. Affected individuals can also have adrenal cortical tumors, carcinoid tumors, and lipomas

The onset of MTC is typically in early childhood in MEN 2B, early adulthood in MEN 2A, and middle age in FMTC.


MEN 1 Syndrome (Wermer's Syndrome)
Triad of
Hyperparathyroidism
Pancreatic Islet Cell Tumours
Pituitery adenoma

MEN 2a Syndrome (Sipple's Syndrome
Medullary Thyroid Carcinoma
Phaeochromocytoma
Hyperparathyroidism


MEN 2b Syndrome
Medullary Thyroid Carcinoma
Phaeochromocytoma
Multiple mucosal neuromas
Ganglioneuromatosis of the gut
Marfanoid appearance

Familial medullary thyroid carcinoma(FMTC)